|
KMID : 0603520030080010053
|
|
Journal of Korean Association of Cancer Prevention
2003 Volume.8 No. 1 p.53 ~ p.58
|
|
|
Selenium and Selenoproteins as the Essential Elements for Spermatogenesis
|
|
Baek In-Jeoung
Nam Sang-Yoon
|
|
|
Abstract
|
|
|
|
Selenium (Se) is an essential micronutrient for mammals and its biological functions are mediated by a selenoprotein. Many studies have shown that the testis is one of the main target organs for Se and that a long Se-deficient state produces abnormal sperms with impaired motility due to characteristic midpiece damage and finally induces a male infertility. In the tests of animals injected an exogenous Se, Se particles are observed mainly in the cytoplasms of spermatogonia, spermatocytes, and Leydig cells. Moreover, the selenoproteins focused on the testis, mitochondrial capsule selenoprotein (MCS) and phospholipid hydroperoxide glutathione peroxidase (PHGPx), are also expressed in the spermatogenic cells and Leydig cells. These indicate that Se and selenoproteins play an important part in the spermatogenesis. In future, to establish the function of Se and selenoprotein during spermatogenesis, more studies would necessary.
|
|
|
KEYWORD
|
|
|
Spermatogenesis, Selenium, Mitochondrial capsule selenoprotein(MCS), Phospholipid hydroperoxide glutathione peroxidase (PHGPx)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|